How it worksEdit

Some animals have a form of suspended animation– hybernation. Two key aspects of hybernation are decrease in metabolic rate and reduction in core body temperature. For humans, a hypometabolic state might have great medical benefit for a variety of conditions, including ischemia and reperfusion injury, pyrexia, and other trauma. Suspended animation–like states may also be useful in surgical situations when delay is sensible for surgical teams, but would be dangerous for the patient.

For humans, most energy comes from oxidative phosphorylation in mitochondria. Inhibiting oxidative phosphorylation produces a state of hypometabolism. Hydrogen sulfide (H2S) is a reversible inhibitor of the electron transport chain in mitochondria. Hyperion 7300 Chamber creates an atmosphere of 80 ppm of H2S, which typically results in an oxygen (O2) consumption drop of ~50% and a carbon dioxide (CO2) output dropped of ~60% within the first 5 minutes. If left in this environment for 6 hours, metabolic rates typically drop to about ~90% of normal. Body temperature will drop dramatically under these conditions, and the Hyperion 7300 Chamber automatically maintains an optimal air temperature, 3 degrees Celsius above the core body temperature. Humans can be maintained in the Hyperion 7300 Chamber for as long as six weeks.

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